Effect of Dopants on the Physical, Mechanical, and Biological Properties of Porous Scaffolds for Bone Tissue Engineering

The design of scaffolds with multifunctional properties is attractive for tissue engineering due to their potential provide and improve the quality life people who require surgery or have bone diseases defects. these applications must be bioactive comply effects biocompatibility biodegradability. They also promote osseointegration facilitate formation on its surface allow adhesion surrounding living when implanted into human body. Bioactive glasses proven suitable fabrication since they are osteoconductive as well osteoinductive. incorporation specific metal ions such Cu, Ag, Mg, Zn, Sr, Co currently interest because can angiogenic osteogenic performance, antibacterial activity, physical mechanical properties. Therefore, this review summarizes effect dopants in various bioglass scaffold compositions. Specific important aspects shown, addition doping elements microstructure, mechanical, thermal properties, bioactivity, cell proliferation, To evaluate viability, several authors manufactured doped multiple resorted studies, including vitro bioactivity analyses simulated body fluid, microbial activity using strains bacteria, cytotoxicity, proliferation lines.